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A hyaluronic acid-based compound inhibits fibroblast senescence induced by oxidative stress in vitro and prevents oral mucositis in vivo.

Protective effect on keratinocytes.

Aminoacid- enriched sodium hyaluronate enhances keratinocyte scattering, chemotaxis and wound healing through integrin β1-dependent mechanisms.

Rapid wound closure.

Topical application of dressing with amino acids improves cutaneous wound healing in aged rats.

Efficacious and safe strategy to accelerate wound healing in elderly subjects leading to improved QoL.

Enhancement of fibroblast proliferation, collagen biosynthesis and production of growth factors as a result of combining sodium hyaluronate and amino acids.

Increased proliferation activity of fibroblasts.

Accelerated wound healing of oral soft tissues and angiogenic effect induced by a pool of amino acids combined to sodium hyaluronate (Aminogam).

Accelerated wound healing and absence of post-operative infections in post-surgery.

New dimensional staging of bisphosphonate-related osteonecrosis of the jaw allowing a guided surgical treatment protocol: long-term follow-up of 266 lesions in neoplastic and osteoporotic patients from the University of Bari.

Accelerated wound and mucosal healing time, reduced time between surgical procedure and suture removal.

Oral soft tissue wound healing after laser surgery with or without a pool of amino acids and sodium hyaluronate: a randomized clinical study.

Wound healing and no complications within 3 weeks after surgery. Statistically significant (p=0.0447) percentage healing index (PHI): 64.38% in study group versus 47.88% in control group.

Sterile gel based on sodium hyaluronate and amino acids: bone healing biological mechanisms in patients treated for third stage bisphosphonate- related osteonecrosis of the jaws (BRONJ).

Decrease in post-operative pain, swelling and infective complications after surgery of oral soft and hard tissues in BRONJ.

Effects of amino acids and sodium hyaluronate (Aminogam) in the post-operative period after surgical laser treatment of oral lesions: a pilot study.

Aminogam versus control group shows: Lower VAS score; Lower AV score; Lower PPI; Lower by 2/3 in the use of NSAIDs in the immediate post-operative period.

Efficacy of a spray compound containing a pool of collagen precursor synthetic amino acids (L Proline, L-Leucine, L-Lysine and Glycine) combined with sodium hyaluronate to manage chemo/radiotherapy induced oral mucositis.

Pain score with VAS significantly reduced after 2 hours of spray administration (p<0.0001, z=-2.803) compared with baseline.

Assessment of the efficacy of a hyaluronic acid and amino acid-based oral spray formulation in “burning mouth syndrome”, with specific regard to gender.

  • Rapid wound healing
  • Reduction of the degree of mucosal de-epithelialisation
  • Higher reduction of pain in study group